Insufficient Evidence for “Autism-Specific” Genes

Evidence for sex-specific risk alleles in autism spectrum disorder.

We investigated the genetic aspects of the large sex bias in the prevalence of autism spectrum disorder by monitoring changes in linkage when the family set for an affected sibling pair genome scan is subdivided on the basis of the sex of affected children. This produces a significant excess in the total number of linkage peaks (P=1.3 x 10(-8)) and identifies a major male-specific linkage peak ...

Insufficient evidence for changing editorial policy.

Dear Editor, With great interest I read the article by Lehmann and Haux [1] in Methods of Information in Medicine (MIM) and the companion article, published in parallel, by Haux and Lehmann [2] in Applied Clinical Informatics (ACI). The authors, who are the respective editors-in-chief of MIM and ACI, evaluate whether the objective to “bridge the divide between ‘bench research’ and applying what...

Chimpanzee Problem Comprehension : Insufficient Evidence

approximately linear rate to 5.5°C. Control and exposure data were obtained between 3.9° and 5.3°C. A blower (100 ft3/min) provided airflow from above. The airflow, measured below the empty chamber with a hot-wire anemometer (Datametrics Airflow Multimeter Model 800 VTP), was approximately 6 m per minute in the region of the lever and increased to approximately 18 m per minute at the opposite s...

The preventive polypill--much promise, insufficient evidence.

Noninvasive carbon monoxide detection: insufficient evidence for broad clinical use.

Carbon monoxide (CO) poisoning is an important public health issue, as this colorless, odorless gas is a common cause of unintentional poisoning and leads to over 400 deaths each year in the United States.1 Detection of CO poisoned patients may be difficult, as even classic symptoms, including headache, nausea, dizziness, and fatigue, are vague and nonspecific, and poisonings may occur without ...